HOMOLOGY MODEL, DOCKING ANALYSIS AND MOLECULAR DYNAMICS SIMULATION OF CANNABINOID CB2 RECEPTOR
نویسندگان
چکیده
منابع مشابه
Regioselectivity of CYP2B6: homology modeling, molecular dynamics simulation, docking.
Human cytochrome P450 (CYP) 2B6 activates the anticancer prodrug cyclophosphamide (CPA) by 4-hydroxylation. In contrast, the same enzyme catalyzes N-deethylation of a structural isomer, the prodrug ifosfamide (IFA), thus causing severe adverse drug effects. To model the molecular interactions leading to a switch in regioselectivity, the structure of CYP2B6 was modeled based on the structure of ...
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ژورنال
عنوان ژورنال: FARMACIA
سال: 2020
ISSN: 0014-8237
DOI: 10.31925/farmacia.2020.2.24